Design, synthesis and antitumor activities of phthalazinone derivatives as PARP-1 inhibitors and PARP-1/HDAC-1 inhibitors
Jie Wu, Xiaoqian Wang, Yaning Yao, Nan Du, Liancheng Duan, Ping Gong
Topics & Concepts
Poly ADP ribose polymeraseChemistryHistone deacetylaseApoptosisIC50Hydroxamic acidCell cycleCell cycle checkpointInhibitory postsynaptic potentialEnzymeCell growthBiochemistryHistonePolymeraseIn vitroStereochemistryDNABiologyNeurosciencePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure Analysis