One-pot domino synthesis of five- and six-membered fused dihydropyridines promoted by PPh<sub>3</sub>–NBS in aqueous medium
Bhanu Prasad Banda, Nagaraju Medishetti, Jagadeesh Babu Nanubolu, A. Krishnaiah
Abstract
, 2-aminochromone, 4-aminochromone, 5-aminopyrazole and 5-aminoisoxazole), β-enaminones and aldehydes in aqueous medium. The present approach involves a Michael type addition followed by intramolecular cyclization leading to the formation of two new C-C bonds and one C-N bond. High compatibility and excellent yields are the advantages of this protocol.
Topics & Concepts
DominoAqueous mediumChemistryAqueous solutionCombinatorial chemistryOrganic chemistryCatalysisMulticomponent Synthesis of HeterocyclesChemical Synthesis and AnalysisSynthesis and Biological Evaluation