Bioinspired Conjugated Tri-Porphyrin-Based Intracellular pH-Sensitive Metallo-Supramolecular Nanoparticles for Near-Infrared Photoacoustic Imaging-Guided Chemo- and Photothermal Combined Therapy
Zhe Zhang, Weiwei Tang, Yufeng Li, Yue Cao, Yuanhong Shang
Abstract
Porphyrins have been extensively used in clinical phototherapy. However, most of them exhibited absorption below 700 nm. We report conjugated tri-porphyrins showing absorption within a biological phototherapy window (700-850 nm). On this basis, bioinspired intracellular pH-sensitive metallo-supramolecular nanoparticles (NPs) are designed. They provide the simultaneous photothermal therapy and chemotherapy. After treatment by tail vein injection, the tumor was completely relieved without recurrence in a course of 27 days. These bioinspired intracellular pH-sensitive metallo-supramolecular NPs show excellent potential application in near-infrared photoacoustic imaging-guided chemo-photothermal combined therapy.