Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
Guangya Zhu, Jingjing Xie, Wenna Kong, Jingfei Xie, Yichen Li, Lin Du, Qiangang Zheng, Lin Sun, Mingfeng Guan, Huan Li, Tianxin Zhu, Hao He, Zhenying Liu, Xi Xia, Kan Chen, Youqi Tao, Hong C. Shen, Dan Li, Siying Wang, Yongguo Yu, Zhihong Yu, Zhong‐Yin Zhang, Cong Liu, Jidong Zhu
Topics & Concepts
BiologyHyperactivationMutantMAPK/ERK pathwayGeneticsSeparation (statistics)DiseaseMutationCell biologySignal transductionGeneInternal medicineMachine learningComputer scienceMedicineProtein Tyrosine PhosphatasesGalectins and Cancer BiologyRNA regulation and disease