The Small RNA MicC Downregulates <i>hilD</i> Translation To Control the Salmonella Pathogenicity Island 1 Type III Secretion System in Salmonella enterica Serovar Typhimurium
Fatih Cakar, Yekaterina A. Golubeva, Carin K. Vanderpool, James M. Slauch
Abstract
The Salmonella pathogenicity island 1 (SPI1) type III secretion system (T3SS) is the primary virulence factor required for causing intestinal disease and initiating systemic infection. The system is regulated in response to a large variety of environmental and physiological factors such that the T3SS is expressed at only the appropriate time and place in the host during infection. Here, we show how the sRNA MicC affects expression of the system. This work adds to our detailed mechanistic studies aimed at a complete understanding of the regulatory circuit.
Topics & Concepts
BiologyPathogenicity islandSalmonella entericaType three secretion systemSalmonellaVirulenceSecretionTranslation (biology)Messenger RNAMicrobiologyRibosomeCell biologyRegulation of gene expressionTranscription (linguistics)Gene expressionOperonIntestinal epitheliumGeneRegulatorGeneticsPost-transcriptional regulationTranscriptional regulationTranslational regulationSerotypeSalmonella and Campylobacter epidemiologyBacterial Genetics and BiotechnologyEscherichia coli research studies