Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation
Wei Yan, Lingtian Zhang, Fengping Lv, Marialuisa Moccia, Francesca Carlomagno, Christophe Landry, Massimo Santoro, Fabien Gosselet, Brendan Frett, Hongyu Li
Topics & Concepts
Trk receptorTropomyosin receptor kinase AChemistryCancer researchTropomyosinKinaseCell cultureCancerColorectal cancerPharmacologyInternal medicineReceptorNeurotrophinBiochemistryMedicineBiologyGeneticsMyosinMelanoma and MAPK PathwaysQuinazolinone synthesis and applicationsCytokine Signaling Pathways and Interactions