Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
Jiaxiang Wu, Jingliang Zhang, Xiaoling Chen, Kyle Wettschurack, Zhefu Que, Brody A. Deming, Maria I. Olivero-Acosta, Ningren Cui, Muriel Eaton, Yuanrui Zhao, Sophia M. Li, Matthew M. Suzuki, Ian Chen, Tiange Xiao, Manasi Halurkar, Purba Mandal, Chongli Yuan, Ranjie Xu, Wendy A. Koss, Dongshu Du, Fuxue Chen, Long‐Jun Wu, Yang Yang
Topics & Concepts
MicrogliaSynaptic pruningNeuroscienceSynapseBiologyAutism spectrum disorderNeurodevelopmental disorderAutismDendritic spineHuman brainImmune systemHippocampusPhenotypeHippocampal formationMedicineImmunologyGeneGeneticsInflammationPsychiatryNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanismsAdenosine and Purinergic Signaling