Isopetasin and S-isopetasin as novel P-glycoprotein inhibitors against multidrug-resistant cancer cells
Sara Abdelfatah, Madeleine Böckers, Maitane Asensio, Onat Kadioglu, Anette Klinger, Edmond Fleischer, Thomas Efferth
Topics & Concepts
P-glycoproteinAbcg2Multiple drug resistanceATP-binding cassette transporterCancer cellDoxorubicinCytotoxicityBiologyPharmacologyChemistryCancer researchBiochemistryCancerTransporterIn vitroChemotherapyGeneticsGeneAntibioticsDrug Transport and Resistance MechanismsPlant Toxicity and Pharmacological PropertiesBiological Activity of Diterpenoids and Biflavonoids