Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide
Zhu-Yan Zhang, Nan Yu, Chang Xue, Shan Gao, Zhao‐Peng Deng, Min Li, Cong Liu, John J. Castellot, Siying Han
Abstract
5-Fluorouracil-nicotinamide (5-FU-NCM), a co-crystal with a 2D layer structure formed by hydrogen bonds, was synthesized by solvent evaporation and liquid phase-assisted grinding at room temperature. Compared to 5-FU alone, the results of solubility, oil-water partition coefficient, anti-tumor effect in vivo and vitro, acute toxicity, and pharmacokinetic parameters indicate that the co-crystal is a potential anti-tumor drug.
Topics & Concepts
NicotinamidePartition coefficientSolubilityIn vivoSolventChemistryHydrogen bondPharmacokineticsCrystal (programming language)Lead glassMaterials scienceChromatographyOrganic chemistryPharmacologyMoleculeMedicineBiotechnologyProgramming languageComputer scienceBiologyEnzymeCrystallography and molecular interactionsCrystallization and Solubility StudiesX-ray Diffraction in Crystallography