Paraformaldehyde as C1 Synthon: Electrochemical Three‐Component Synthesis of Tetrahydroimidazo[1,5‐<i>a</i>]quinoxalin‐4(5<i>H</i>)‐ones in Aqueous Ethanol
Yuhan Lu, Si‐Yu Mu, Jun Jiang, Min‐Hang Zhou, Chao Wu, Hong‐Tao Ji, Wei‐Min He
Abstract
A green and practical method for the electrochemical synthesis of tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones through the three-component reaction of quinoxalin-2(1H)-ones, N-arylglycines and paraformaldehyde was reported. In this strategy, EtOH played dual roles (eco-friendly solvent and waste-free pre-catalyst) and the in situ generated ethoxide promoted triple sequential deprotonations.
Topics & Concepts
ParaformaldehydeSynthonChemistryCatalysisElectrochemistryAqueous solutionSolventEthanolCombinatorial chemistryOrganic chemistryElectrodePhysical chemistrySynthesis and Biological EvaluationMulticomponent Synthesis of HeterocyclesCatalytic C–H Functionalization Methods