Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists
Benjamin J. Huffman, Shuming Chen, J. Luca Schwarz, R. Erik Plata, Emily N. Chin, Luke L. Lairson, K. N. Houk, Ryan A. Shenvi
Topics & Concepts
ButenolideChemistryChemical spaceStereochemistryDrug discoveryNatural productCombinatorial chemistryBiochemistryinterferon and immune responsesCytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways