New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis
Ismail M. M. Othman, Mohamed A. M. Gad‐Elkareem, El Hassane Anouar, Kaïss Aouadi, Mejdi Snoussi, Adel Kadri
Topics & Concepts
ChemistryDocking (animal)SulfonamidePeroxiredoxinAntimicrobialStereochemistryAutoDockABTSMolecular modelPyrazolonesIn vitroEnzymeDHPSBiochemistryAntioxidantBiologyMedicinal chemistryOrganic chemistryPeroxidaseDPPHGeneImmunologyMalariaPlasmodium falciparumNursingIn silicoMedicineSynthesis and biological activityBioactive Compounds and Antitumor AgentsMetal complexes synthesis and properties