Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation
Julia Katharina Scholz, Andre Kraus, Dominik Lüder, Kathrin Skoczynski, Mario Schiffer, Steffen Grampp, Johannes Schödel, Bjoern Buchholz
Abstract
, cAMP impaired tubule formation after capillary-induced injury which was further impaired by loss Polycystin-1.
Topics & Concepts
PKD1CystPolycystic kidney diseaseEndocrinologyInternal medicinePhenotypeTubuleAutosomal dominant polycystic kidney diseaseCell biologyMedicineKidneyBiologyPathologyGeneGeneticsGenetic and Kidney Cyst DiseasesBiomedical Research and PathophysiologyHedgehog Signaling Pathway Studies