Lipid droplet dynamics regulate adult muscle stem cell fate
Feng Yue, Stephanie N. Oprescu, Jiamin Qiu, Lijie Gu, Lijia Zhang, Jingjuan Chen, Naagarajan Narayanan, Meng Deng, Shihuan Kuang
Abstract
cells in self-renewal and regeneration in vivo. Pharmacological inhibition of LD biogenesis or genetic inhibition of LD catabolism through knockout of Pnpla2 (encoding ATGL, the rate-limiting enzyme for lipolysis) disrupts cell fate homeostasis and impairs the regenerative capacity of SCs. Dysfunction of Pnpla2-null SCs is associated with energy insufficiency and oxidative stress that can be partially rescued by antioxidant (N-acetylcysteine) treatment. These results establish a direct link between LD dynamics and stem cell fate determination.
Topics & Concepts
Cell biologyStem cellBiologyCell fate determinationRegeneration (biology)Skeletal muscleCellBiochemistryEndocrinologyGeneTranscription factorLipid metabolism and biosynthesisAdipose Tissue and MetabolismMuscle metabolism and nutrition