Applications of High Performance Liquid Chromatography in the Petroleomic Analysis of Crude Oil: A Mini-Review
Nicole E. Heshka
Abstract
High performance liquid chromatography (HPLC) is a well established analytical technique in the study of crude oil, and it has recently become more integrated within the field of petroleomics as a first step before high-resolution mass spectrometric analysis. This mini-review summarizes and discusses the applications of HPLC for the analyses of crude oil and its related products that have been published over the last 10 years. A brief introduction to separation science is provided, and applications are divided by compound class (group-type separations, heteroatoms, and other specialty analytes). Special attention is paid to applications that specifically couple to Fourier Transform ion cyclotron resonance mass spectrometry, and these are discussed in a separate section.