Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
Minghui Wang, Aiqun Li, Michiko Sekiya, Noam D. Beckmann, Xiuming Quan, Nadine Schrode, Michael B. Fernando, Alex W. Yu, Li Zhu, Jiqing Cao, Liwei Lyu, Emrin Horgusluoglu, Qian Wang, Lei Guo, Yuanshuo Wang, Ryan Neff, Won‐Min Song, Erming Wang, Qi Shen, Xianxiao Zhou, Ming Chen, Seok‐Man Ho, Sezen Vatansever, H. Ümit Kanıskan, Jian Jin, Ming‐Ming Zhou, Kanae Ando, Lap Ho, Paul A. Slesinger, Zhenyu Yue, Jun Zhu, Pavel Katsel, Sam Gandy, Michelle E. Ehrlich, Valentina Fossati, Scott Noggle, Dongming Cai, Vahram Haroutunian, Koichi Iijima, Eric E. Schadt, Kristen Brennand, Bin Zhang
Topics & Concepts
NeuroscienceInduced pluripotent stem cellRegulatorBiologyNeurodegenerationSubnetworkDiseaseComputational biologyGene silencingPhenotypeGene regulatory networkGeneComputer scienceMedicineGene expressionGeneticsEmbryonic stem cellPathologyComputer securityAlzheimer's disease research and treatmentsBioinformatics and Genomic NetworksGenetics, Aging, and Longevity in Model Organisms