Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer
Xing Fei Tan, Qifan Chen, San Hue Hua, George W. Yip
Abstract
The Interferon-induced protein with tetratricopeptide repeats (IFIT) family is an important component of the antiviral immune response. There are currently four known IFIT family members in humans, namely IFIT1, IFIT2, IFIT3 and IFIT5. Recent discoveries have brought attention to the significant roles of IFITs in cancer. This review summarises current knowledge on the biological roles of different IFIT proteins in various types of malignant neoplasm, and highlights the potential use of these molecules as cancer biomarkers and prognostic factors.
Topics & Concepts
TetratricopeptideInterferonCancerBiologyComputational biologyImmune systemGeneticsGeneinterferon and immune responsesHepatitis C virus researchRNA modifications and cancer