Ruthenium-Catalyzed C(sp<sup>2</sup>)–H Bond Bisallylation with Imidazopyridines as Directing Groups
Shuang Liu, Hui Jiang, Wannian Liu, Xinju Zhu, Xin‐Qi Hao, Mao‐Ping Song
Abstract
A Ru(II)-catalyzed bisallylation of imidazopyridines with vinylcyclopropanes or vinyl cyclic carbonate has been successfully realized. Notably, pharmacophore imidazopyridine was utilized as an intrinsic directing group, which gave access to value-added bisallylated products in high yields via double tandem C-H and C-C/C-O activation. The current methodology was featured with broad substrate scope, good functional group compatibility, and operational simplicity.
Topics & Concepts
ChemistryPharmacophoreCatalysisRutheniumCombinatorial chemistryCarbeneImidazopyridineMedicinal chemistrySubstrate (aquarium)TandemCompatibility (geochemistry)StereochemistryOrganic chemistryGeologyGeochemistryOceanographyMaterials scienceComposite materialCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms