Balancing activation and co-stimulation of CAR tunes signaling dynamics and enhances therapeutic potency
Yanting Duan, Jiangqing Chen, Xianhui Meng, Longwei Liu, Kai Shang, Xiaoyan Wu, Yajie Wang, Zihan Huang, Houyu Liu, Yanjie Huang, Chun Zhou, Xiaofei Gao, Yingxiao Wang, Jie Sun
Topics & Concepts
Cancer researchIn vivoPotencyIn vitroCD19CD28Co-stimulationChemistryFörster resonance energy transferCD3Immunoreceptor tyrosine-based activation motifCell biologyFlow cytometryBiologySignal transductionMolecular biologyAntigenTyrosine kinaseCytotoxic T cellImmunologyCD8BiochemistrySH2 domainFluorescenceGeneticsPhysicsQuantum mechanicsCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology