Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases
Maria Latacz, Jadwiga Snarska, Elżbieta Kostyra, Ewa Fiedorowicz, Huub F. J. Savelkoul, Roman Grzybowski, Anna Cieślińska
Abstract
Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin D activation. This review presents gathered data that relate to genetic variants in CYP27B1 gene in correlation to multiple diseases, mostly concerning colorectal, prostate, breast, lung, and pancreatic cancers, as well as on other pathologies, such as non-Hodgkin’s lymphoma, oral lichen planus, or multiple sclerosis.
Topics & Concepts
Single-nucleotide polymorphismGeneAlpha (finance)BiologyMedicineGeneticsGenotypeInternal medicineEndocrinologyCancer researchSurgeryPatient satisfactionConstruct validityVitamin D Research StudiesFolate and B Vitamins ResearchGrowth Hormone and Insulin-like Growth Factors