IDO1 can impair NK cells function against non-small cell lung cancer by downregulation of NKG2D Ligand via ADAM10
Xin Fang, Leilei Guo, Zikang Xing, Lei Shi, Heng Liang, Aiying Li, Chunxiang Kuang, Bangbao Tao, Qing Yang
Topics & Concepts
NKG2DDownregulation and upregulationIndoleamine 2,3-dioxygenaseCancer researchA549 cellAryl hydrocarbon receptorChemistryCell biologyBiologyCellCytotoxic T cellTranscription factorIn vitroBiochemistryGeneAmino acidTryptophanTryptophan and brain disordersImmune Cell Function and InteractionImmune cells in cancer