SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells
Keith Meyer, Tapas Patra, Vijayamahantesh Vijayamahantesh, Ranjit Ray
Abstract
) treated with CM exhibited an increase in cellular senescence markers by a paracrine mode and led to leukocyte adhesion. Overall, the link between these responses in endothelial cell senescence and a potential contribution to microvascular complication in productively SARS-CoV-2-infected humans is implicated. Furthermore, the use of inhibitors (BTK, IL-6, and BRD4) showed a reverse effect in the senescent cells. These results may support the selection of potential adjunct therapeutic modalities to impede SARS-CoV-2-associated pathogenesis.
Topics & Concepts
BiologyParacrine signallingCell biologySpike (software development)Spike ProteinSenescenceAdhesionCellular senescenceVirologyImmunologyCoronavirus disease 2019 (COVID-19)PhenotypeGeneticsInfectious disease (medical specialty)PathologyChemistryMedicineDiseaseEconomicsGeneOrganic chemistryReceptorManagementVirus-based gene therapy researchSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies