BCR-ABL1-driven exosome-miR130b-3p-mediated gap-junction Cx43 MSC intercellular communications imply therapies of leukemic subclonal evolution
Chengyan Chai, Ke Sui, Jun Tang, Hao Yu, Chao Yang, Hongyang Zhang, Shengwen Calvin Li, Jiang F. Zhong, Zheng Wang, Xi Zhang
Abstract
Our findings shed light on how leukemia BCR-ABL1-driven exosome-miR130b-3p could interact with gap-junction Cx43, and further impact GJIC in TME, implications for leukemic therapies of subclonal evolution.
Topics & Concepts
ExosomeMesenchymal stem cellBiologyStem cellCell biologyStromal cellMicrovesiclesCancer researchBone marrowHaematopoiesisTranscriptomeProgenitor cellmicroRNAImmunologyGene expressionGeneticsGeneExtracellular vesicles in diseaseMesenchymal stem cell researchHematopoietic Stem Cell Transplantation