Highly enantioselective access to chiral chromanes and thiochromanes <i>via</i> Cu-catalyzed hydroamination with anthranils
Xiaodong Gu, Ling Meng, Mingliang Li, Jun Wang
Abstract
Highly efficient and atom-economic asymmetric access to 4-arylamino chromanes and thiochromanes bearing a benzylic alcohol functionality were developed by Cu(<sc>i</sc>)/(<italic>R</italic>,<italic>R</italic>)-Ph-BPE-catalyzed enantioselective hydroamination with anthranils.
Topics & Concepts
HydroaminationEnantioselective synthesisChemistryCatalysisAlcoholCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions