Hepatitis B Virus Small Envelope Protein Promotes Hepatocellular Carcinoma Angiogenesis via Endoplasmic Reticulum Stress Signaling To Upregulate the Expression of Vascular Endothelial Growth Factor A
Shu-Xiang Wu, Shuang-Shuang Ye, Yu-Xiang Hong, Yan Chen, Biao Wang, Xin-Jian Lin, Xu Lin
Abstract
. Mechanistically, SHBs induced endoplasmic reticulum (ER) stress, which consequently activated unfolded protein response (UPR) signaling to increase VEGFA expression and secretion. This study suggests that SHBs plays an important proangiogenic role in HBV-associated HCC and may represent a potential target for antiangiogenic therapy in HCC.
Topics & Concepts
AngiogenesisBiologyVascular endothelial growth factor AEndoplasmic reticulumCancer researchHepatocellular carcinomaVascular endothelial growth factorHepatitis B virusUmbilical veinUnfolded protein responseProtein kinase AKinaseVascular endothelial growth factor CEndothelial stem cellGrowth factorDownregulation and upregulationNeovascularizationHBsAgMolecular biologyCell biologyVascular endothelial growth factor BCell cultureCancer cellTumor microenvironmentLiver cancerSignal transductionGlucose-regulated proteinHepatitis B Virus StudiesHepatocellular Carcinoma Treatment and PrognosisEndoplasmic Reticulum Stress and Disease