Beyond the TPP<sup>+</sup>“gold standard”: a new generation mitochondrial delivery vector based on extended PN frameworks
How Chee Ong, João T. S. Coimbra, Maria J. Ramos, Bengang Xing, Pedro Alexandrino Fernandes, Felipe Garcı́a
Abstract
PN frameworks were explored as mitochondrial delivery vectors. The newly designed phosphazenylphosphonium moiety was demonstrated to be more effective than traditional triphenylphosphonium-based vectors.
Topics & Concepts
Delivery systemChemistryNanotechnologyCombinatorial chemistryComputer scienceMaterials scienceEngineeringBiomedical engineeringMitochondrial Function and PathologyBoron Compounds in ChemistryOrgan Transplantation Techniques and Outcomes