EGR1 Promotes Erastin-induced Ferroptosis Through Activating Nrf2-HMOX1 Signaling Pathway in Breast Cancer Cells
Zhirong Lin, Zifei Liu, Zhilong Pan, Yunyi Zhang, Xinyu Yang, Yaxin Feng, Ruihua Zhang, Wenfeng Zeng, Chang Gong, Jianing Chen
Abstract
The expression of EGR1 is downregulated in BC, which is correlated with poor prognosis of BC patients. EGR1 suppresses the proliferation of BC cells and facilitates erastin-induced ferroptosis by activating Nrf2-HMOX1 signaling pathway in BC cells.
Topics & Concepts
EGR1Transcription factorCancer researchZinc fingerZinc finger transcription factorHMOX1Breast cancerCell biologySignal transductionCancerChemistryBiologyGeneGeneticsBiochemistryEnzymeHemeHeme oxygenaseFerroptosis and cancer prognosisRNA modifications and cancerCancer-related gene regulation