Synthesis of Cyclopropylamines through an Electro-Induced Hofmann Rearrangement
André B. Charette, Thomas Poisson, Philippe Jubault, Thomas Cantin
Abstract
Abstract A practical access to cyclopropylamines from the corresponding amides is disclosed, according to an electro-induced Hofmann rearrangement. In an undivided cell under galvanostatic conditions, a panel of cyclopropyl amides was readily converted into the corresponding amines (17 examples, 23% to 94% yield). This reaction allowed an easy access to the versatile cyclopropylamines and is complementary to the existing methods.
Topics & Concepts
ChemistryYield (engineering)Combinatorial chemistryMedicinal chemistryMetallurgyMaterials scienceCyclopropane Reaction MechanismsAsymmetric Synthesis and CatalysisCatalytic Cross-Coupling Reactions