Progress in LRRK2-Associated Parkinson’s Disease Animal Models
Steven P. Seegobin, George R. Heaton, Dongxiao Liang, Insup Choi, Marian Blanca Ramírez, Beisha Tang, Zhenyu Yue
Abstract
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of familial Parkinson’s disease (PD). Several genetic manipulations of the LRRK2 gene have been developed in animal models such as rodents, Drosophila, C. elegans, and zebrafish. These models can help us further understand the biological function and derive potential pathological mechanisms for LRRK2. Here we discuss common phenotypic themes found in LRRK2-associated PD animal models, highlight several issues that should be addressed in future models and discuss emerging areas to guide their future development.
Topics & Concepts
LRRK2Parkinson's diseaseNeuroscienceDiseaseMedicineBiologyPathologyParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsNuclear Receptors and Signaling