Cocrystal Solubility Advantage and Dose/Solubility Ratio Diagrams: A Mechanistic Approach To Selecting Additives and Controlling Dissolution–Supersaturation–Precipitation Behavior
Katie L. Cavanagh, Gislaine Kuminek, Naír Rodríguez‐Hornedo
Abstract
are key thermodynamic parameters to understanding the kinetic cocrystal behavior and how the risks of cocrystal development may be mitigated through the mechanistic formulation design.
Topics & Concepts
CocrystalSupersaturationSolubilityDissolutionPrecipitationChemistryNucleationChemical engineeringThermodynamicsOrganic chemistryMoleculeHydrogen bondMeteorologyPhysicsEngineeringCrystallization and Solubility StudiesCrystallography and molecular interactionsPhenothiazines and Benzothiazines Synthesis and Activities