Dipeptidyl peptidase-4 cell surface expression marks an abundant adipose stem/progenitor cell population with high stemness in human white adipose tissue
Florian M. Hatzmann, Sonja Großmann, Petra Waldegger, G. Jan Wiegers, Markus Mandl, Tina Rauchenwald, Gerhard Pierer, Werner Zwerschke
Abstract
ASC located in the vascular stroma surrounding small blood vessels and in mature adipocytes. We conclude that DPP4 is a functional marker for an abundant ASC population in human WAT with high proliferation and self-renewal potential and low adipogenic differentiation capacity.
Topics & Concepts
AdipogenesisAdipose tissueProgenitor cellStem cellCell biologyBiologyCD34PopulationAdipocyte3T3-L1White adipose tissueCellular differentiationEndocrinologyMedicineBiochemistryGeneEnvironmental healthPancreatic function and diabetesAdipose Tissue and MetabolismTissue Engineering and Regenerative Medicine