Treponema pallidum Macrolide Resistance and Molecular Epidemiology in Southern Africa, 2008 to 2018
Johanna M. E. Venter, E Müller, Mahlape P. Mahlangu, Ranmini Kularatne
Abstract
gene sequence types, were identified. There was an association between A2058G-associated macrolide resistance and T. pallidum strain types 14d/f and 14d/g but no association between T. pallidum macrolide resistance and HIV coinfection. The majority of T. pallidum strains, as well as strains containing the A2058G mutation, belonged to the SS14-like clade. This is the first study to extensively detail the molecular epidemiology and emergence of macrolide resistance in T. pallidum in southern Africa.
Topics & Concepts
TreponemaAzithromycinBiologyVirologyMolecular epidemiologyCoinfectionDrug resistance23S ribosomal RNASyphilisAntibiotic resistanceMicrobiologyGenotypeAntibioticsGeneticsGeneVirusHuman immunodeficiency virus (HIV)RibosomeRNASyphilis Diagnosis and TreatmentReproductive tract infections researchSex work and related issues