Chemical profiles, pharmacological properties, and in silico studies provide new insights on Cycas pectinata
Abu Montakim Tareq, Saifuddin Farhad, A Uddin, Muminul Hoque, Shamima Nasrin, Mir Md. Rokib Uddin, Mohiminul Hasan, Arafat Sultana, Mst Shirajum Munira, Chadni Lyzu, S. M. Moazzem Hossen, A.S.M. Ali Reza, Talha Bin Emran
Abstract
value of 631.44 μg/mL. MECP (62.5-500 μg/mL) elicited 20.96-38.12% decreased protein denaturation compared to diclofenac sodium (65.40-83.50%), while a 35.72% (P < 0.001) clot lysis activity was observed for the 10 mg/mL concentration. MECP induced a dose-dependent reduction in locomotor activity, with a significant anxiolytic effect. In the analgesic test, MECP (200, 400 mg/kg) showed a 45.12% and 58.82% inhibition in analgesia, and the 400 mg/kg dose elicited a 27.5% inhibition in intestinal motility. These findings suggest that MECP might be effective in treating antioxidant, anti-inflammatory, and neuropharmacological defects, but this requires further study.