<i>Poria cocos</i> oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis
Ke Lan, Huabing Yang, Junping Zheng, Haiming Hu, Tianxiang Zhu, Xiaojuan Zou, Baifei Hu, Hongtao Liu
Abstract
PCOs. Finally, using antibiotic mixtures to destroy the intestinal bacteria, we documented that PCO fermentation broth (PCO FB) instead of PCOs prevented the occurrence of colitis in gut microbiota-depleted mice. In conclusion, PCOs showed a protective effect on colitis by reversing gut microbiota dysbiosis. Our study sheds light on the potential application of PCOs as a prebiotic for treating colitis.
Topics & Concepts
ColitisDysbiosisGut floraMicrobiologyInflammatory bowel diseaseMucinPrebioticBacteriaBiologyImmunologyChemistryPharmacologyMedicineInternal medicineFood scienceBiochemistryDiseaseGeneticsGut microbiota and healthProbiotics and Fermented FoodsInflammatory Bowel Disease