Effect of Vitamin D on Paraxonase‐1, Total Antioxidant Capacity, and 8‐Isoprostan in Children with Attention Deficit Hyperactivity Disorder
Niyaz Mohammadzadeh Honarvar, Mahsa Samadi, Marzieh Seyedi Chimeh, Fatemeh Gholami, Niki Bahrampour, Mahmoud Jalali, Mohammad Effatpanah, Mir Saeed Yekaninejad, Mina Abdolahi, Maryam Chamari
Abstract
Background and Objective . Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders in children. Increased oxidative stress and decreased vitamin D may be associated with neurodevelopmental and psychiatric disorders, such as ADHD. The purpose of this study was to investigate the effect of vitamin D supplementation on oxidative stress in children with attention deficit hyperactivity disorder. Method . In this double‐blind, randomized, placebo‐controlled trial, 75 children (aged 6–12) diagnosed with ADHD were randomly assigned into two groups. The supplementation group received vitamin D3 (2000 IU), and the control group received a placebo for 3 months. Blood samples were collected at baseline and after intervention to analyze the 25(OH)D, paraxonase‐1 activity (PON‐1), Total Antioxidant Capacity (TAC), and 8‐isoprostan levels. Results . A significant rise in circulating 25(OH)D was observed in the vitamin D group versus the placebo group at the end of the study. There was no reduction in 8‐isoprostan levels in the vitamin D group compared to the placebo group. Serum paraxonase‐1 and TAC concentration decreased in both groups, but these alterations were not statistically significant in the treatment group versus the placebo group at the end of the intervention. Conclusion . Vitamin D supplementation for 3 months did not have beneficial effects on biomarkers of oxidative stress status. To confirm these findings, further studies on children are suggested.