Iridium(III)-Catalyzed C(3)–H Alkylation of Isoquinolines via Metal Carbene Migratory Insertion
Neha Jha, Roushan Prakash Singh, Paridhi Saxena, Manmohan Kapur
Abstract
-acetyl-1,2-dihydroisoquinolines with diverse acceptor-acceptor diazo compounds has been achieved under a single catalytic system via metal carbene migratory insertion. Moreover, further synthetic transformations of the alkylated products such as aromatization, selective decarboxylation, and decarbonylation lead to the formation of several synthetically viable isoquinoline derivatives having immense potentials.
Topics & Concepts
ChemistryCarbeneAlkylationIsoquinolineIridiumDecarbonylationMigratory insertionDiazoCatalysisDecarboxylationAromatizationAcceptorMedicinal chemistryMetalCombinatorial chemistryOrganic chemistryCondensed matter physicsPhysicsCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis