Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease
Akihiro Nakamura, Fanxing Zeng, Sayaka Nakamura, Kyle T Reid, Eric Gracey, Melissa Lim, Lin Leng, Sungsin Jo, Ye‐Soo Park, Masaki Kusuda, Rohan Machhar, Shaghayegh Foroozan-Boroojeni, Brian Wu, Evgeny Rossomacha, Tae‐Hwan Kim, Francesco Ciccia, Jason S. Rockel, Mohit Kapoor, Robert D. Inman, Igor Jurišica, Sarah Q. Crome, Richard Bucala, Nigil Haroon
Abstract
17 phenotype. These results indicate that MIF is a crucial regulator and a potential therapeutic target in type 3 immunity-mediated arthritis.
Topics & Concepts
Macrophage migration inhibitory factorImmunologyCurdlanProinflammatory cytokineMonokineMedicineCytokineArthritisInflammationInterleukinBiologyBiochemistryPolysaccharideMacrophage Migration Inhibitory FactorNuclear Receptors and Signaling