Apoferritin-Encapsulated Jerantinine A for Transferrin Receptor Targeting and Enhanced Selectivity in Breast Cancer Therapy
Haneen Abuzaid, Salah Abdelrazig, Lenny Ferreira, Hilary M. Collins, Dong‐Hyun Kim, Kuan‐Hon Lim, Toh‐Seok Kam, Lyudmila Turyanska, Tracey D. Bradshaw
Abstract
< 0.01). Decreased PLK1 and Mcl-1 expression, together with the appearance of cleaved poly (ADP-ribose)-polymerase, corroborate the augmented potency of AFt-JAa. Hence, we demonstrate that AFt represents a biocompatible vehicle for targeted delivery of JAa, offering potential to minimize toxicity and enhance JAa activity in TfR1-expressing tumors.
Topics & Concepts
SKBR3Transferrin receptorCancer researchChemistryCancer cellCell cultureReceptorCancerBiologyMedicineInternal medicineBiochemistryGeneticsHuman breastAdvanced biosensing and bioanalysis techniquesProtein Degradation and InhibitorsRNA Interference and Gene Delivery