Enantioselective propargylic substitution reactions via transition metal–allenylidene complexes as key intermediates
Yoshiaki Tanabe, Yoshiaki Nishibayashi
Abstract
Significant progress has been made in recent years in the development of enantioselective propargylic substitution reactions using transition metal complexes as catalysts. In particular, several enantioselective propargylic substitution reactions have been developed with the formation of transition metal–allenylidene complexes as key reactive intermediates. This review focuses on the recent advances in the development of enantioselective propargylic substitution reactions via transition metal–allenylidene complexes as key intermediates. • Enantioselective propargylic substitution reactions via the formation of transition metal (Ru or Cu)–allenylidene complexes as key intermediates • Well-defined molecular catalysts as well as combination of transition metal compounds with chiral ligands or organocatalysts • Typical examples of asymmetric induction including the isolation of allenylidene complexes