Direct optogenetic stimulation of smooth muscle cells to control gastric contractility
Markus Vogt, Benjamin Schulz, Ahmed Wagdi, Jan Lebert, Gijsbert J. van Belle, Jan Christoph, Tobias Bruegmann, Robert Patejdl
Abstract
We demonstrate direct optogenetic stimulation of SMC to control gastric contractility. This completely new approach could allow for the restoration of motility in gastroparesis in the future.
Topics & Concepts
OptogeneticsGastroparesisInterstitial cell of CajalStimulationDepolarizationAntrumGastric emptyingPeristalsisHyperpolarization (physics)StomachMembrane potentialMedicineInternal medicineAnatomyNeuroscienceChemistryBiologySmooth muscleNuclear magnetic resonance spectroscopyOrganic chemistryPhotoreceptor and optogenetics researchCircadian rhythm and melatoninNeuroscience and Neural Engineering