Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
Thijmen van Vliet, Marta Varela-Eirín, Boshi Wang, Michela Borghesan, Simone Brandenburg, Rossana Franzin, Konstantinos Evangelou, Marc A. Seelen, Vassilis G. Gorgoulis, Marco Demaria
Topics & Concepts
BiologySenescenceAMPKParacrine signallingPhenotypePI3K/AKT/mTOR pathwayHypoxia (environmental)Cell biologyReactive oxygen speciesMechanistic target of rapamycinSignal transductionCancer researchPhosphorylationReceptorOxygenProtein kinase ABiochemistryChemistryGeneOrganic chemistryTelomeres, Telomerase, and SenescenceNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancer