Ligand-Enabled Pd(II)-Catalyzed C(sp<sup>3</sup>)–H Lactonization Using Molecular Oxygen as Oxidant
Shaoqun Qian, Zi‐Qi Li, Minyan Li, Steven R. Wisniewski, Jennifer X. Qiao, Jeremy M. Richter, William R. Ewing, Martin D. Eastgate, Jason S. Chen, Jin‐Quan Yu
Abstract
-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biologically important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing.
Topics & Concepts
ChemistryCatalysisMolecular oxygenBenzoic acidOxygenLigand (biochemistry)OxygenationNitrogenCombinatorial chemistryMoleculePalladiumMedicinal chemistryOrganic chemistryReceptorBiochemistryBiologyEcologyCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions