Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond
Chao Mao, Min Wang, Li Zhuang, Boyi Gan
Abstract
Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism. This review discusses the mechanisms of metabolic cell death-ferroptosis, cuproptosis, disulfidptosis, lysozincrosis, and alkaliptosis-and explores their potential in cancer therapy. Our review underscores the complexity of the metabolic cell death pathways and offers insights into innovative therapeutic avenues for cancer treatment.
Topics & Concepts
Human geneticsDevelopmental biologyProgrammed cell deathBiologyCancerStem cellCancer researchCell biologyApoptosisGeneticsGeneFerroptosis and cancer prognosisRNA modifications and cancerCancer, Lipids, and Metabolism