Study of the Characterization of Side Population Cells in Endometrial Cancer Cell Lines: Chemoresistance, Progestin Resistance, and Radioresistance
Bingjie Liu-Lastres, Qiying Xu, Weidong Yu, Na Li, Tian Yao, Lijun Zhao, Jianliu Wang, Lihui Wei, Xiaoping Li
Abstract
There is a significant enrichment in SP cells among different EC cell lines, and these SP cells be more resistant to Taxol, MPA and radiation therapy. The overexpression of BCRP among SP cells may be the cause of resistance to Taxol, progestin and radiotherapy, which may be related to apoptosis and autophagic activity.
Topics & Concepts
RadioresistanceEndometrial cancerProgestinCancer researchOncologyPopulationHeLaCell cultureInternal medicineMedicineBiologyCancerRadiation therapyGeneticsHormoneEnvironmental healthCancer Cells and MetastasisMicroRNA in disease regulationEstrogen and related hormone effects