Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells
Sun‐Hee Jang, Eui-Jong Kwon, Jennifer Lee
Abstract
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets.
Topics & Concepts
Rheumatoid arthritisImmunologyPannusAutoantibodyPathogenesisChemokineMedicineImmune systemAutoimmune diseaseArthritisAntibodyRheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus ResearchChronic Lymphocytic Leukemia Research