Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke
Jing Ye, Xinyuan Bi, Shiyu Deng, Xianghui Wang, Ze Liu, Qian Suo, Jiao Wu, Hao Chen, Yong Wang, Kun Qian, Rubing Shi, Jing Zhao, Guo-Yuan Yang, Jian Ye, Yaohui Tang
Abstract
Our study identified hypoxanthine as an important metabolite that induces vascular injury and BBB disruption in stroke through triggering GSDME-dependent pyroptosis of endothelial cells.
Topics & Concepts
PyroptosisHypoxanthineBiomarkerStroke (engine)Ischemic strokeMedicineChemistryCancer researchIschemiaCardiologyApoptosisBiochemistryProgrammed cell deathEnzymeEngineeringMechanical engineeringInflammasome and immune disordersHeme Oxygenase-1 and Carbon Monoxide