Dual stimulus-triggered bioorthogonal nanosystem for spatiotemporally controlled prodrug activation and near-infrared fluorescence imaging
Zhongyi Zhao, Qingyu Zong, Jun Li, Maolin Jiang, Kewei Wang, Youyong Yuan
Abstract
In this study, we combined low pH and cathepsin B dual-stimulus-triggered delivery carriers with a bioorthogonal reaction-activated prodrug to achieve regulated activation of the prodrug. A workable method for precise tumor therapy and imaging is provided by the bioorthogonal reaction, which activates the prodrug and fluorescent probe.
Topics & Concepts
Bioorthogonal chemistryProdrugChemistryFluorescenceFluorescence-lifetime imaging microscopyBiophysicsCombinatorial chemistryBiochemistryClick chemistryPhysicsQuantum mechanicsBiologyNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery