Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing <i>in vitro</i> Fertilization and Embryo Transfer: A Large Retrospective Cohort Study.
Xiao Yan Gai, Hong Bin, Lin Zeng, Wen Li Cao, Li Xue Chen, Chen Zhang, Ming Lu, Lan Ding Ning, Chun Chang, Wei Xia Zhang, Ping Liu, Rong Li, Yong Chang Sun, Jie Qiao
Abstract
OBJECTIVE: fertilization and embryo transfer (IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET. METHOD: We conducted a retrospective cohort study of 14,254 infertile patients who had received IVF-ET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth, clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB groups. RESULTS: = 0.011) rates in patients with unexplained infertility. CONCLUSIONS: Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population.