Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy
Antônio Rafael Quadros Gomes, Natasha Cunha, Everton Luiz Pompeu Varela, Heliton Patrick Cordovil Brígido, Valdicley Vieira Vale, Maria Fâni Dolabela, Eliete Pereira de Carvalho, Sandro Percário
Abstract
Malaria is an infectious disease and a serious public health problem in the world, with 3.3 billion people in endemic areas in 100 countries and about 200 million new cases each year, resulting in almost 1 million deaths in 2018. Although studies look for strategies to eradicate malaria, it is necessary to know more about its pathophysiology to understand the underlying mechanisms involved, particularly the redox balance, to guarantee success in combating this disease. In this review, we addressed the involvement of oxidative stress in malaria and the potential benefits of antioxidant supplementation as an adjuvant antimalarial therapy.