Serum Thyroglobulin Measurement Following Surgery Without Radioactive Iodine for Differentiated Thyroid Cancer: A Systematic Review
Roger Chou, Tracy Dana, Gregory A. Brent, Whitney Goldner, Megan R. Haymart, Angela M. Leung, Matthew D. Ringel, Julie Ann Sosa
Abstract
Very limited evidence suggests low utility of Tg measurement for identifying recurrent or metastatic disease following partial thyroidectomy. Following total/near-total thyroidectomy, Tg levels using a cutoff of 1-2.5 ng/mL might identify patients at low risk for persistent or metastatic disease. Additional research is needed to clarify the role of Tg measurement in these settings, determine optimal Tg thresholds, and determine appropriate measurement intervals.
Topics & Concepts
MedicineThyroidectomyThyroid cancerThyroglobulinTotal thyroidectomyPapillary thyroid cancerInternal medicineThyroidGastroenterologyUrologyThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid SurgeryThyroid Disorders and Treatments